Trifluoromethylation of heterocycles via visible light photoredox catalysis

Abstract

A method has been developed for the visible light-induced trifluoromethylation of heterocyclic compounds. A variety of electron-rich heterocycles were transformed into trifluoromethylated products by using CF3I as the trifluoromethyl radical source and Ru(bpy)3Cl2 as the photocatalyst under mild reaction conditions. This operationally simple and eco-friendly process can introduce trifluoromethyl groups without prefunctionalization.This research was supported by the National Research Foundationof Korea (NRF) under Grant NRF-2011-0013118