Development of a Safe and Economical Synthesis of
Methyl 6‑Chloro-5-(trifluoromethyl)nicotinate: Trifluoromethylation
on Kilogram Scale

Jason A. Mulder (1676344); Rogelio P. Frutos (1944787); Nitinchandra
D. Patel (1676338); Bo Qu (150402); Xiufeng Sun (1923685); Thomas G. Tampone (1944778); Joe Gao (1434067); Max Sarvestani (1688401); Magnus C. Eriksson (1944784); Nizar Haddad (1392799); Sherry Shen (1944781); Jinhua J. Song (1433575); Chris H. Senanayake (1392808)

textjournal article

Development of a Safe and Economical Synthesis of Methyl 6‑Chloro-5-(trifluoromethyl)nicotinate: Trifluoromethylation on Kilogram Scale

Authors: Jason A. Mulder (1676344)
Rogelio P. Frutos (1944787)
Nitinchandra D. Patel (1676338)
Bo Qu (150402)
Xiufeng Sun (1923685)
Thomas G. Tampone (1944778)
Joe Gao (1434067)
Max Sarvestani (1688401)
Magnus C. Eriksson (1944784)
Nizar Haddad (1392799)
Sherry Shen (1944781)
Jinhua J. Song (1433575)
Chris H. Senanayake (1392808)
Publication date: 19 February 2016
Publisher
Doi

Abstract

Reported herein is a safe and economical synthesis of methyl 6-chloro-5-(trifluoromethyl)nicotinate, an intermediate in the synthesis of novel anti-infective agents. The key to this process is the trifluoromethylation of an aryl iodide using an inexpensive methyl chlorodifluoroacetate (MCDFA)/KF/CuI system, with an emphasis on the development work which led to this effective process

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The Francis Crick Institute

oai:figshare.com:article/24035...

Last time updated on 12/02/2018

This paper was published in The Francis Crick Institute.

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