A novel series of positive modulators of the AMPA receptor : structure-based lead optimization

Jamieson, Craig; Campbell, Robert A.; Cumming, Iain A.; Gillen, Kevin J.; Gillespie, Jonathan; Kazemier, Bert; Kiczun, Michael; Lamont, Yvonne; Lyons, Amanda J.; Maclean, John K.F.; Martin, Frederic; Moir, Elizabeth M.; Morrow, John A.; Pantling, John; Rankovic, Zoran; Smith, Lynn

oai:strathprints.strath.ac.uk:27801

A novel series of positive modulators of the AMPA receptor : structure-based lead optimization

Authors: Craig Jamieson
Robert A. Campbell
Iain A. Cumming
Kevin J. Gillen
Jonathan Gillespie
Bert Kazemier
Michael Kiczun
Yvonne Lamont
Amanda J. Lyons
John K.F. Maclean
Frederic Martin
Elizabeth M. Moir
John A. Morrow
John Pantling
Zoran Rankovic
Lynn Smith
Publication date: 15 October 2010
Publisher
Doi

Abstract

Starting from lead compound 1, we demonstrate how x-ray structural data can be used to understand SAR and expediently optimize bioavailability in a novel series of AMPA receptor modulators, furnishing 5 with improved bioavailability and robust in vivo activity

QD
QD

Similar works

Full text

Open in the Core reader

Download PDF

University of Strathclyde Institutional Repository

oai:strathprints.strath.ac.uk:...

Last time updated on 01/08/2012

This paper was published in University of Strathclyde Institutional Repository.

Having an issue?

Is data on this page outdated, violates copyrights or anything else? Report the problem now and we will take corresponding actions after reviewing your request.