Article thumbnail

CKAMP44: a brain-specific protein attenuating short-term synaptic plasticity in the dentate gyrus

By J. von Engelhardt, V. Mack, R. Sprengel, N. Kavenstock, K. Li, Y. Stern-Bach, A. Smit, P. Seeburg and H. Monyer

Abstract

CKAMP44, identified here by a proteomic approach, is a brain-specific type I transmembrane protein that associates with AMPA receptors in synaptic spines. CKAMP44 expressed in Xenopus oocytes reduced GluA1- and A2-mediated steady-state currents, but did not affect kainate- or N-methyl-D-aspartate (NMDA) receptor-mediated currents. Mouse hippocampal CA1 pyramidal neurons expressed CKAMP44 at low abundance, and overexpression of CKAMP44 led to stronger and faster AMPA receptor desensitization, slower recovery from desensitization, and a reduction in the paired-pulse ratio of AMPA currents. By contrast, dentate gyrus granule cells exhibited strong CKAMP44 expression, and CKAMP44 knockout increased the paired-pulse ratio of AMPA currents in lateral and medial perforant path-granule cell synapses. CKAMP44 thus modulates short-term plasticity at specific excitatory synapses

Year: 2010
DOI identifier: 10.1126/science.1184178
OAI identifier: oai:escidoc.org:escidoc:2395106
Provided by: MPG.PuRe
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • https://www.ncbi.nlm.nih.gov/p... (external link)
  • http://hdl.handle.net/11858/00... (external link)
  • http://hdl.handle.net/11858/00... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.