Sculponins A-C, three new 6,7-seco-ent-kauranoids from Isodon sculponeatus

Li, LM; Li, GY; Ding, LS; Lei, C; Yang, LB; Zhao, Y; Weng, ZY; Li, SH; Huang, SX; Xiao, WL; Han, QB; Sun, HD; Sun, HD, Chinese Acad Sci, Kunming Inst Bot, State Key LPhytochem & Plant Resources W China, Kunming 650204, Peoples R China.

research article

oai:210.75.237.14:351003/17971

Sculponins A-C, three new 6,7-seco-ent-kauranoids from Isodon sculponeatus

Authors: LM Li
GY Li
LS Ding
C Lei
LB Yang
Y Zhao
ZY Weng
SH Li
SX Huang
WL Xiao
QB Han
HD Sun
HD, Chinese Acad Sci, Kunming Inst Bot, State Key LPhytochem & Plant Resources W China, Kunming 650204, Peoples R China. Sun
Publication date: 1 January 2007
Publisher
Doi

Abstract

Three new 6,7-seco-eni-kauranoids (1-3) were isolated and structures were elucidated from Isodon sculponeatus. Diterpenoids 1-3 possessing multicyclic skeletons formed via oxygen atoms are all unprecedented among ent-kauranes. Compound I displayed significant cytotoxic activity against K562, A549, and HepG2 human tumor cell lines, with IC50 values of 1.4, 2.3, and 2.0 mu M, respectively, equal to the positive control. Plausible pathways for the biosynthesis of I and 2 from one related diterpenoid were also postulated. (C) 2007 Elsevier Ltd. All rights reserved

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oai:210.75.237.14:351003/17971

Last time updated on 29/11/2016

This paper was published in Institutional Repository of Chengdu Institute of Biology, CAS.

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