OBJECTIVES: This study aimed to develop further a diary originally devised to measure the impact of multiple
sclerosis (MS) as part of a cost utility study of beta interferon, and to evaluate its reliability, validity, and
responsiveness in an outpatient sample of people with MS.
METHODS: The original diary was further developed using qualitative and quantitative methods to ensure
that it addressed the views of people with MS. The psychometric properties of the MS Symptom and Impact
Diary (MSSID) were evaluated in a sample of 77 people who completed the MSSID daily for 12 weeks.
Internal and test–retest reliability, discriminant and convergent validity, and responsiveness were assessed
using traditional psychometric methods.
RESULTS: The MSSID formed three, internally consistent scales that measured mobility, fatigue, and the
overall impact of MS. The test–retest reliability of the mobility scale was adequate for individual
comparisons (ICC.0.90) and the fatigue and overall impact scales were adequate for group comparisons
(ICC.0.70). The MSSID was able to distinguish between clinical groups depending on clinical course,
indoor ambulation status, and relapse status. It demonstrated associations with other single point
instruments in the expected direction. Compared with single point instruments, its responsiveness was
similar or better, especially in detecting short term improvements in functioning.
CONCLUSIONS: The MSSID may provide a useful complement to currently available instruments to measure
the outcomes of MS within clinical trials. Further research is needed to explore its feasibility in the context
of a randomised controlled trial and its utility for clinicians
Is data on this page outdated, violates copyrights or anything else? Report the problem now and we will take corresponding actions after reviewing your request.