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Evidence for antibiotic induced Clostridium perfringens\ud diarrhoea\ud

By N. Modi and M.H. Wilcox


Clostridium difficile is a well documented\ud cause of antibiotic associated diarrhoea in\ud hospitalised patients, but may account for\ud only approximately 20% of all cases. This\ud leader reviews the current knowledge and\ud understanding of the pathogenesis, epidemiology,\ud and diagnosis of non-food borne\ud Clostridium perfringens diarrhoea. Although\ud enterotoxigenic C perfringens has\ud been implicated in some C difficile negative\ud cases of antibiotic associated diarrhoea,\ud C perfringens enterotoxin detection\ud methods are not part of the routine\ud laboratory investigation of such cases.\ud Testing for C perfringens enterotoxin in\ud faecal samples from patients with antibiotic\ud associated diarrhoea and sporadic\ud diarrhoea on a routine basis would have\ud considerable resource implications.\ud Therefore, criteria for initiating investigations\ud and optimum laboratory tests need\ud to be established. In addition, establishing\ud the true burden of C perfringens antibiotic\ud associated diarrhoea is important\ud before optimum control and treatment\ud measures can be defined.\u

Year: 2001
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