Skip to main content
Article thumbnail
Location of Repository

Structural changes in rat Pneumocystis carinii surface antigens after terbinafine administration in experimental P. carinii pneumonia

By C. Contini, E. Angelici and R. Canipari


Terbinafine is a synthetic antifungal agent which has recently been found to be highly effective\ud against Pneumocystis carinii. This study evaluated the efficacy of terbinafine on rat P. carinii\ud antigenic profile and the immune response by Western blot analysis, in comparison with\ud atovaquone and co-trimoxazole in rats with pneumocystosis. Terbinafine was shown to target\ud two specific major antigens, particularly those of 116 and 35–40 kDa. Antibodies reactive\ud against these moieties were found in all rats treated with atovaquone and co-trimoxazole, but\ud not in those treated with terbinafine. These surface antigen modifications could be related to\ud disease severity and could provide additional information for monitoring the efficacy of this\ud treatment

Topics: Pneumocystis carinii, PCP, Terbinafine, Rat, Western blot
Year: 1999
OAI identifier:
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • (external link)
  • Suggested articles

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.