Terbinafine is a synthetic antifungal agent which has recently been found to be highly effective
against Pneumocystis carinii. This study evaluated the efficacy of terbinafine on rat P. carinii
antigenic profile and the immune response by Western blot analysis, in comparison with
atovaquone and co-trimoxazole in rats with pneumocystosis. Terbinafine was shown to target
two specific major antigens, particularly those of 116 and 35–40 kDa. Antibodies reactive
against these moieties were found in all rats treated with atovaquone and co-trimoxazole, but
not in those treated with terbinafine. These surface antigen modifications could be related to
disease severity and could provide additional information for monitoring the efficacy of this
treatment
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