Genetic polimorphism of serotonin transporter and Monoaine Oxidase and response to SSRI antidepressant drugs interminal cancer patients.
The Serotonin transporter (SERT) and monoaminooxidase play an important role in monoaminergic transmission and in mood regulation. The 5HTLTTPR polimorphism and the VNTR for MAO were studied among 73 terminal patients with depression. Citaloproam and sertraline were used to treat depression. Efficacy of the 2 drugs was higher in patients with the genetic polimorphism conferring high functional activity of MAO VNTR
5HTTLPR polimorphism, VNTR polimorphism, depression, SSRIS
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