Phenolic Compounds from the Roots of Jordanian Viper's Grass, Scorzonera judaica.

Abstract

Nine new phenolic compounds, 3S-hydrangenol 4'-O-alpha-L-rhamnopyranoysl-(1 -> 3)-beta-D-glucopyranoside (1), thunberginol F 7-O-beta-D-glucopyranoside (2), 2-hydroxy6-[2-(4-hydroxyphenyl)-2-oxo-ethyl]benzoic acid (3), 2-hydroxy-6-[2-(3,4-dihydroxyphenyl)-2-oxo-ethyl]benzoic acid (4), 2-hydroxy-6-[2-(3,4-dihydroxyphenyl-5-methoxy)-2-oxo-ethyl]benzoic acid (5), hydrangeic acid 4'-O-beta-D-glucopyranoside (6), E-3-(3,4-dihydroxybenzylidene)-5-(3,4-dihydroxyphenyl)dihydrofuran-2-one (7), Z-3-(3,4-dihydroxybenzylidene)-5-(3,4-dihydroxyphenyl)-2(3H)-furanone (8), and 4-[beta-D-glucopyranosyl)hydroxy]-pinoresinol (9), and nine known compounds were isolated from the roots of Scorzonera judaica. Structures of 1-9 were elucidated by mass spectrometry, extensive 1D and 2D NMR spectroscopy, and CD spectroscopy. All compounds were evaluated for cytotoxic activity