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Pancreatitis-diabetes-pancreatic cancer: summary of an NIDDK-NCI workshop

By Dana K. Andersen, Åke Andren-Sandberg, Eric J. Duell, Michael Goggins, Murray Korc, Gloria M. Petersen, Jill P. Smith and David C. Whitcomb

Abstract

A workshop sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the National Cancer Institute (NCI) on "Pancreatitis-Diabetes-Pancreatic Cancer" focused on the risk factors of chronic pancreatitis (CP) and diabetes mellitus (DM) on the development of pancreatic ductal adenocarcinoma (PDAC). Sessions were held on (a) an overview of the problem of PDAC; (b) CP as a risk factor of PDAC; (c) DM as a risk factor of PDAC; (d) pancreatogenic, or type 3c, DM; (e) genomic associations of CP, DM, and PDAC; (f) surveillance of high-risk populations and early detection of PDAC; and (g) effects of DM treatment on PDAC. Recent data and current understandings of the mechanisms of CP- and DM-associated factors on PDAC development were discussed, and a detailed review of the possible risks of DM treatment on the development of PDAC was provided by representatives from academia, industry, and the Food and Drug Administration. The current status of possible biomarkers of PDAC and surveillance strategies for high-risk populations were discussed, and the gaps in knowledge and opportunities for further research were elucidated. A broad spectrum of expertise of the speakers and the discussants provided an unusually productive workshop, the highlights of which are summarized in the accompanying article

Topics: Carcinoma, Pancreatic Ductal -- etiology, Carcinoma, Pancreatic Ductal -- prevention & control, Diabetes Complications -- etiology, Diabetes Complications -- prevention & control, Diabetes Mellitus -- therapy, Humans, National Institute of Diabetes and Digestive and Kidney Diseases (U.S.), Pancreatic Neoplasms -- etiology, Pancreatic Neoplasms -- prevention & control, Pancreatitis, Chronic -- complications, Pancreatitis, Chronic -- therapy, Risk Factors, United States
Publisher: Wolters Kluwer
Year: 2013
DOI identifier: 10.1097/MPA.0b013e3182a9ad9d
OAI identifier: oai:scholarworks.iupui.edu:1805/6916
Provided by: IUPUIScholarWorks

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