Skip to main content
Article thumbnail
Location of Repository

Barrier disruption in STAT6VT transgenic mice as a potential model for atopic dermatitis skin inflammation

By Sonia Cristina DaSilva

Abstract

Indiana University-Purdue University Indianapolis (IUPUI)Atopic dermatitis (AD) is a pruritic, chronic inflammatory skin disease with a lifetime prevalence of 10-20% in children and 1-3% in adults, worldwide. In the past three decades, prevalence of the disease has increased by two to three-fold in industrialized countries, with higher incidences in urban regions compared to rural regions. Mice with an activating mutation in STAT6, known as STAT6VT, constitutively express STAT6 in T-cells. Our preliminary data suggests significant differences between the STAT6VT transgenic mice from WT littermate controls treated with SLS. These findings correlate with evidence that there are abnormalities in the barrier function between these mic

Topics: STAT6VT transgenic mice Atopic Dermatitis, Atopic dermatitis -- Research, T cells
Year: 2011
OAI identifier: oai:scholarworks.iupui.edu:1805/2488
Provided by: IUPUIScholarWorks

Suggested articles


To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.