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DECIPHERING CELL SIGNALING REWIRING IN HUMAN DISORDERS

By Inna Kuperstein

Abstract

The knowledge of cell molecular mechanisms implicated in human diseases is expanding and should be converted into guidelines for deciphering pathological cell signaling and suggesting appropriate treatment. The basic assumption is that during a pathological transformation, the cell does not create new signaling mechanisms, but rather it hijacks the existing molecular programs. This affects not only intracellular functions, but also a crosstalk between different cell types resulting in a new, yet pathological status of the system. There is a certain combination of molecular characteristics dictating specific cell signaling states that sustains the pathological disease status. Identifying and manipulating the key molecular players controlling these cell signaling states, and shifting the pathological status toward the desired healthy phenotype, are the major challenge for molecular biology of human diseases

Topics: Network Data Analysis, Cancer Research, [ SDV ] Life Sciences [q-bio], [ SDV.BIBS ] Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], [ SDV.BC ] Life Sciences [q-bio]/Cellular Biology, [ SDV.CAN ] Life Sciences [q-bio]/Cancer, [ SDV.NEU ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Publisher: HAL CCSD
Year: 2015
OAI identifier: oai:HAL:tel-01248439v1
Provided by: Thèses en Ligne

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