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Haplotypes of vitamin D receptor modulate the circulating levels of lead in exposed subjects

By Vania B. REZENDE, Fernando BARBOSA JR., Marcelo F. MONTENEGRO, Valeria C. SANDRIM, Raquel F. GERLACH and Jose E. TANUS-SANTOS

Abstract

Genetic factors influence whole blood lead (Pb-B) concentrations in lead exposed subjects. This study aimed at examining the combined effects (haplotype analysis) of three polymorphisms (BsmI, ApaI and FokI) in vitamin D receptor (VDR) gene on Pb-B and on the concentrations of lead in plasma (Pb-P), which is more relevant to lead toxicity, in 150 environmentally exposed subjects. Genotypes were determined by RFLP, and Pb-P and Pb-B were determined by inductively coupled plasma mass spectrometry and by graphite furnace atomic absorption spectrometry, respectively. Subjects with the bb (BsmI polymorphism) or ff (FokI polymorphism) genotypes have lower B-Pb than subjects in the other genotype groups. Subjects with the aa (ApaI polymorphism) or ff genotypes have lower P-Pb than subjects in the other genotype groups. Lower Pb-P, Pb-B, and %Pb-P/Pb-B levels were found in subjects with the haplotype combining the a, b, and f alleles for the ApaI, BsmI, and FokI polymorphisms, respectively, compared with the other haplotype groups, thus suggesting that VDR haplotypes modulate the circulating levels of lead in exposed subjects

Topics: haplotype, polymorphism, plasma lead, toxicogenetics, vitamin D receptor, whole blood lead, AMINOLEVULINIC-ACID DEHYDRATASE, OXIDE SYNTHASE GENES, WHOLE-BLOOD LEAD, PATELLA LEAD, RENAL-FUNCTION, POLYMORPHISMS, ASSOCIATIONS, WORKERS, PLASMA, BONE, Toxicology
Publisher: SPRINGER
Year: 2013
OAI identifier: oai:agregador.ibict.br.RI_UNICAMP:oai:unicamp.sibi.usp.br:SBURI/533
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