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SINTESIS DE 1-ARIL-2-NITROALQUENOS ANTITUMORALES

By Bruce Cassels Niven, S. Herreros, C. Ibáñez, M. C. Rozende, S. Sepúlveda and C. Sebastián

Abstract

l-Aryl-2-nitroalkenes can. ba synthesized mest convéniently by refluxing aromatic aidehydes with nitromethane 01' nitroethane in acetic acid using n-butyla llIineas a catalyst •.{ In this way' seventeen nev cOIIl'PC'lmdosf this type aad seve-raI known ana10gues withalkaxy andhalo ring substituents ware prepared. without the CODcurrent production ol the corref5l'011dingly' substituted benzonitrii_. Moat of thes!! compounds were- tested in theP-J88 murine 1ympbocytic leuk.emia aseay; {QUr of them pc~s_sed reproducible antitumor activity, and another five gav& si~ficantiy increased survival times wtri.ch _re not rept'OducedEste trabajo se realizó con el financiamiento de DICYT (USACH)

Publisher: Asoc. Quím. Argentina
Year: 1981
OAI identifier: oai:repositorio.uchile.cl:2250/119551
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