Introduction: amyloidosis is the extracellular accumulation of amyloid material,
which causes damage in the functioning of organs and tissues. It is characterized
by the presence of protein folding, which acquire the capacity of self-assembly
creating unusual configurations.
Case reports: the case reports of two female patients are presented. Both with
47 years of age, who died without clinical diagnosis. Due to not evident cause
of the deaths, clinical autopsies were carried out. Massive presence of amyloid
in different organs was found, which was confirmed with the Congo red staining
method and the assessment in the polarized light microscopy. Multiple organ
dysfunction syndromes secondary to the presence of systemic amyloidosis was
diagnosed and in both patients was considered as the cause of death.
Conclusion: the clinical symptoms of the amyloidosis are variable and nonspecific,
depending of the extracellular deposits and its location in the body. It
is a challenge to do a diagnosis. It is recommended to consider the diagnostic
possibility of the amyloidosis in patients with suggestive symptoms of damage
in the function of the organ and it is required the histological confirmation. Rev.
cienc.biomed. 2014;5(1):123-129
KEYWORDS
Amyloid, Amyloid beta-protein precursor, Amyloidosis, Autopsy
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