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Effect of curcumin, the active constituent of turmeric, on penicillin-induced epileptiform activity in rats

By Esmaeal Tamaddonfard, Amir Erfanparast, Nasrin Hamzeh-Gooshchi and Shahnaz Yousofizadeh


Objective: Curcumin is a major constituent of turmeric and has many biological functions such as anticancer and anti-inflammatory effects. The present study was conducted to investigate the effects of curcumin and diazepam in separate and combined treatments on penicillin-induced seizures in rats. Materials and Methods: In urethane-anesthetized rats, epileptiform activity was induced by intracortical (i.c.) administration of penicillin (200 IU, 1 µl), and frequency and amplitude of spike waves were analyzed using electrocorticographic recordings. Results: Intraperitoneal (i.p.) injections ofcurcumin at doses of 100 and 200 mg/kg, and intracerebroventricular (i.c.v.) injection of diazepam at a dose of 5 µg significantly (

Topics: Curcumin, Diazepam, Penicillin-Induced Seizures, Rats, Therapeutics. Pharmacology, RM1-950
Publisher: Mashhad University of Medical Sciences
Year: 2012
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