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SEARCH FOR CELL VOLUME SENSORS: AN UPDATE

By S. N. Orlov and R. Grygorszyk

Abstract

Cell volume changes affect a plethora of cellular functions including macromolecular synthesis and catabolism, cell proliferation, differentiation and death. Because of these critical roles, cells regulate their volume with <1% accuracy via compensatory mechanisms termed regulatory volume increase and regulatory volume decrease. Our review focuses on recent advances in understanding the molecular origin of up-stream sensors triggering cellular responses to volume perturbations. The analysis demonstrates a major  role  of  cytoplasmic  hydrogel  as  well  as  the  crosstalk  of  polyphosphoinositides  and  twodimensional cytoskeleton (membrane carcass) in cell volume sensing

Topics: cell volume, membrane stretch, cytoskeleton, biogel, Medicine, R
Publisher: Siberian State Medical University (Tomsk)
Year: 2013
OAI identifier: oai:doaj.org/article:6e0417b92d324fd0a32c1566c7edd62b
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