Highly Acetylated Lanostane-Type Triterpenoids from Coprinus cinereus 120

Abstract

National Science Fund for Distinguished Young Scholars [30325044]; Chinese Ministry of Education [306010]; 973 Program [2010CB833802]Two new highly acetylated lanostane-type triterpenoids, coprinacin A (1) and coprinacin B (2), were isolated from the basidiomycetous strain Coprinus cinereus 120. The chemical structures of 1 and 2 were elucidated by spectroscopic analyses, including 1D- and 2D-NMR experiments and FT-ICR-MS, and their in vitro cytotoxic activities against the human-tumor cell line HeLa were established as modest