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oaioai:dspace.xmu.edu.cn:2288/63588

Copper-induced cytotoxicity: reactive oxygen species or islet amyloid polypeptide oligomer formation

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Publication date
1 January 2010
Publisher
Doi

    Abstract

    Copper enhances amyloid cytotoxicity and mediates human islet amyloid polypeptide (hIAPP) oligomerization; nickel, a redox inactive metal with similar protein binding affinity to copper, also mimics this effect, thereby demonstrating copper-mediated hIAPP cytotoxicity is due mainly to granular oligomer generation rather than ROS accumulation in type 2 diabetes

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    Xiamen University Institutional Repository

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    Last time updated on 16/06/2016

    This paper was published in Xiamen University Institutional Repository.

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