High prevalence of celiac disease in Brazilian blood donor volunteers based on screening by IgA antitissue transglutaminase antibody

Abstract

Objective: To study the prevalence of celiac disease among blood donor volunteers based on screening by IgA antitissue transglutaminase antibody, followed by a confirmatory small intestine biopsy.Methods: the transversal study involved 3000 potential blood donors, residing in the city of São Paulo, Brazil. the participants were gender divided into 1500 men and 1500 women, with an average age 34.4 +/- 10.8 years, and included blood donor volunteers who could be turned down owing to anemia. All participants answered a questionnaire concerning the presence of diarrhea, constipation or abdominal pain during the 3 months before the study. Each participant with human recombinant IgA antitissue transglutaminase antibody level above 10 U/ml was invited to undergo a small intestine biopsy by means of an upper gastrointestinal endoscopy. the presence of villous atrophy and a positive antibody test were suggestive of possible celiac disease.Results: Antitissue transglutaminase antibody was positive in 1.5% (45/3000) of the study population. Among the anti body-positive group, 21 (46.6%) agreed to have a biopsy performed, and within them the histological pattern of villous atrophy was confirmed in 66.7% (14/21). Consequently, the suggestive prevalence of celiac disease was at the minimum, one per 214 of the potential blood donor volunteers. A significant association was found between celiac disease and the symptoms of diarrhea, constipation and abdominal pain.Conclusions: the prevalence of celiac disease in São Paulo city is high and comparable to that observed in European countries. It is possible that in Brazil the prevalence of this disease had previously been underestimated.Universidade Federal de São Paulo, Paulista Sch Med, Div Pediat Gastroenterol, São Paulo, BrazilUniversidade Federal de São Paulo, Paulista Sch Med, Blood Collect Benefit Assoc Colsan, Dept Hematol & Hemotherapy, São Paulo, BrazilUniversidade Federal de São Paulo, Paulista Sch Med, Dept Pathol, São Paulo, BrazilUniversidade Federal de São Paulo, Paulista Sch Med, Div Pediat Gastroenterol, São Paulo, BrazilUniversidade Federal de São Paulo, Paulista Sch Med, Blood Collect Benefit Assoc Colsan, Dept Hematol & Hemotherapy, São Paulo, BrazilUniversidade Federal de São Paulo, Paulista Sch Med, Dept Pathol, São Paulo, BrazilWeb of Scienc