Straightforward preparation of enantiopure 3-amino-4,4-dimethylpyrrolidin-2-one and its derivatives

Abstract

12 páginas, 3 figuras, 1 tabla, 7 esquemas.-- et al.An easy access to both enantiomers of 3-amino- and 3-(dimethylamino)-4,4-dimethylpyrrolidin-2-one from rac-pantolactam using (R)-α-methylbenzylamine as a chiral auxiliary is described.Financial support from Ministerio de Ciencia e Innovación (Project CTQ2008-03768/PPQ) and Comissionat per a Universitats i Recerca (Project 2005-SGR-00180) is gratefully acknowledged.Peer reviewe