Immunochemical determination of xenobiotics with endocrine disrupting effects

Abstract

13 pages, 4 schemes, 2 tables.-- PMID: 14564440 [PubMed].-- Available online Oct 16, 2003.This paper is a review with more than 100 references discussing the immunochemical methods reported in the literature for the most important man-made chemicals with suspected endocrine disrupting activity. Details regarding immunizing hapten design, antibody production, and the features (limit of detection, dynamic range, specificity) of the most important immunochemical methods developed (ELISA, FIIA, immunosorbents, immunosensors, etc.) are presented for important environmental pollutants such as bisphenol A, phthalates, alkylphenol polyethoxylates, alkylphenols, polychlorinated biphenyl compounds, and dioxins. Availability of commercial reagents and methods is reported.This work was supported by INIA (VIN00–053-C3–2), the EC Quality of Life Program (Contract QLRT-2000–01670), and by CICYT (BIO2000–0351-P4–05, AGL2001–5005-E and AGL2002–04635-C04–03).Peer reviewe