journal article
oaioai:www.repository.cam.ac.uk:1810/254785

IP3 receptors: Take four IP3 to open.

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    Publication date
    4 April 2016
    Publisher
    American Association for the Advancement of Science
    Doi

      Abstract

      Inositol 1,4,5-trisphosphate receptors (IP3Rs) and ryanodine receptors are the channels responsible for Ca(2+)release from the endoplasmic and sarcoplasmic reticulum. Research inScience Signalingby Alzayadyet al show that all four IP3-binding sites within the tetrameric IP3R must bind IP3before the channel can open, which has important consequences for the distribution of both IP3and IP3R activity within cells

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      This paper was published in Apollo (Cambridge).

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