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Simple and convenient preparation of novel 6,8-disubstituted quinoline derivatives and their promising anticancer activities

By Salih Okten, Osman Cakmak, Ramazan Erenler, Onem Yuce and Saban Tekin

Abstract

Okten, Salih/0000-0001-9656-1803; Erenler, Ramazan/0000-0002-0505-3190WOS: 000326936200005A short and easy route is described for 6,8-disubstituted derivatives of quinoline and 1,2,3,4-tetrahydroquinoline from 6,8-dibromoquinolines 2 and 7 by various substitution reactions. While copper-promoted substitution of 6,8-dibromide 2 produced monomethoxides 3 and 4, a prolonged reaction time mainly afforded dimethoxide 6 instead of 5, whose aromatization with DDQ and substitution reaction of dibromide 7 with NaOMe in the presence of CuI also gave rise to dimethoxide 6. Several 6,8-disubstituted quinolines were obtained by treatment of 6,8-dibromoquinoline (7) with n-BuLi followed by trapping with an electrophile [Si(Me)(3)Cl, S-2(Me)(2), and DMF]. Furthermore, 7 was also converted to mono and dicyano derivatives. The anticancer activities of compounds 2, 7, 6, 12, 13, 15, and 16 against HeLa, HT29, and C6 tumor cell lines were tested, and 6,8-dibromo-1,2,3,4-tetrahydroquinoline (2) and 6,8-dimethoxyquinoline (6) showed significant anticancer activities against the tumor cell lines.Scientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [112T394]This study was supported by grants from the Scientific and Technological Research Council of Turkey (TUBITAK, Project number: 112T394)

Topics: Anticancer effect, bromoquinoline, cyanoquinoline, lithium-bromine exchange, methoxyquinoline, quinoline derivatives
Publisher: 'The Scientific and Technological Research Council of Turkey'
Year: 2013
DOI identifier: 10.3906/kim-1301-30
OAI identifier: oai:acikerisim.kku.edu.tr:20.500.12587/5620
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