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A general theory of DNA-mediated and other valence-limited colloidal interactions.

By Patrick Varilly, Stefano Angioletti-Uberti, Bortolo Matteo Mognetti and Daan Frenkel


We present a general theory for predicting the interaction potentials between DNA-coated colloids, and more broadly, any particles that interact via valence-limited ligand-receptor binding. Our theory correctly incorporates the configurational and combinatorial entropic factors that play a key role in valence-limited interactions. By rigorously enforcing self-consistency, it achieves near-quantitative accuracy with respect to detailed Monte Carlo calculations. With suitable approximations and in particular geometries, our theory reduces to previous successful treatments, which are now united in a common and extensible framework. We expect our tools to be useful to other researchers investigating ligand-mediated interactions. A complete and well-documented Python implementation is freely available at ArticleResearch Support, Non-U.S. Gov'tinfo:eu-repo/semantics/publishe

Topics: Sciences exactes et naturelles, Colloids, DNA -- chemistry, DNA, Single-Stranded -- chemistry, Monte Carlo Method
Year: 2012
DOI identifier: 10.1063/1.4748100
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Provided by: DI-fusion
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