Activation of AMP-activated protein kinase inhibits oxidized LDL-triggered endoplasmic reticulum stress in vivo
Abstract
The oxidation of LDLs is considered a key step in the development of atherosclerosis. How LDL oxidation contributes to atherosclerosis remains poorly defined. Here we report that oxidized and glycated LDL (HOG-LDL) causes aberrant endoplasmic reticulum (ER) stress and that the AMP-activated protein kinase (AMPK) suppressed HOG-LDL-triggered ER stress in vivo- article
- info:eu-repo/semantics/publishedVersion
- AMP-Activated Protein Kinases
- Animals
- Aorta
- Apolipoproteins E
- Cattle
- Crosses, Genetic
- Endoplasmic Reticulum
- Endothelium, Vascular
- Enzyme Activation
- Gene Expression Regulation
- Humans
- Lipoproteins, LDL
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- RNA, Small Interfering
- Umbilical Veins
Similar works
Full text
Last time updated on 23/09/2013
This paper was published in Queen's University Belfast Research Portal.
Having an issue?
Is data on this page outdated, violates copyrights or anything else? Report the problem now and we will take corresponding actions after reviewing your request.