Lower vascular tone and larger plasma volume in Parkinson's disease with orthostatic hypotension

Abstract

Contains fulltext : 98070.pdf (publisher's version ) (Closed access)The pathophysiology of orthostatic hypotension in Parkinson's disease (PD) is incompletely understood. The primary focus has thus far been on failure of the baroreflex, a central mediated vasoconstrictor mechanism. Here, we test the role of two other possible factors: 1) a reduced peripheral vasoconstriction (which may contribute because PD includes a generalized sympathetic denervation); and 2) an inadequate plasma volume (which may explain why plasma volume expansion can manage orthostatic hypotension in PD). We included 11 PD patients with orthostatic hypotension (PD + OH), 14 PD patients without orthostatic hypotension (PD - OH), and 15 age-matched healthy controls. Leg blood flow was examined using duplex ultrasound during 60 degrees head-up tilt. Leg vascular resistance was calculated as the arterial-venous pressure gradient divided by blood flow. In a subset of 9 PD + OH, 9 PD - OH, and 8 controls, plasma volume was determined by indicator dilution method with radiolabeled albumin ((125)I-HSA). The basal leg vascular resistance was significantly lower in PD + OH (0.7 +/- 0.3 mmHg.ml(-1).min) compared with PD - OH (1.3 +/- 0.6 mmHg.ml(-1).min, P < 0.01) and controls (1.3 +/- 0.5 mmHg.ml(-1).min, P < 0.01). Leg vascular resistance increased significantly during 60 degrees head-up tilt with no significant difference between the groups. Plasma volume was significantly larger in PD + OH (3,869 +/- 265 ml) compared with PD - OH (3,123 +/- 377 ml, P < 0.01) and controls (3,204 +/- 537 ml, P < 0.01). These results indicate that PD + OH have a lower basal leg vascular resistance in combination with a larger plasma volume compared with PD - OH and controls. Despite the increase in leg vascular resistance during 60 degrees head-up tilt, PD + OH are unable to maintain their blood pressure