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The long non-coding RNA LSINCT5 promotes malignancy in non-small cell lung cancer by stabilizing HMGA2

By Yuheng Tian (5352653), Nali Zhang (5485979), Shuwen Chen (4229206), Yuan Ma (189824) and Yanyan Liu (171941)


<p>Long non-coding RNAs (lncRNAs) can actively participate in tumorigenesis in various cancers. However, the involvement of lncRNA long stress induced non-coding transcripts 5 (LSINCT5) in non-small cell lung cancer (NSCLC) remains largely unknown. Here we showed a novel lncRNA signature in NSCLC through lncRNA profiling. Increased LSINCT5 expression positively correlates with malignant clinicopathological features and poor survival. LSINCT5 can promote migration and viability of various NSCLC cells <i>in vitro</i> and also enhance lung cancer progression <i>in vivo</i>. RNA immunoprecipitation followed by mass spectrometry has identified that LSINCT5 interacts with HMGA2. This physical interaction can increase the stability of HMGA2 by inhibiting proteasome-mediated degradation. Therefore, LSINCT5 may possibly contribute to NSCLC tumorigenesis by stabilizing the oncogenic factor of HMGA2. This novel LSINCT5/HMGA2 axis can modulate lung cancer progression and might be a promising target for pharmacological intervention.</p

Topics: Biophysics, Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Cancer, Hematology, Virology, Biological Sciences not elsewhere classified, LSINCT5, HMGA2, NSCLC
Year: 2018
DOI identifier: 10.6084/m9.figshare.6463328.v2
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Provided by: FigShare
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