High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy

Hasson, Samuel A.; Kane, Lesley A.; Yamano, Koji; Huang, Chiu-Hui; Sliter, Danielle A.; Buehler, Eugen; Wang, Chunxin; Heman-Ackah, Sabrina M.; Hessa, Tara; Guha, Rajarshi; Martin, Scott E.; Youle, Richard J.

research article

High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy

Authors: Samuel A. Hasson
Lesley A. Kane
Koji Yamano
Chiu-Hui Huang
Danielle A. Sliter
Eugen Buehler
Chunxin Wang
Sabrina M. Heman-Ackah
Tara Hessa
Rajarshi Guha
Scott E. Martin
Richard J. Youle
Publication date: 24 November 2013
Publisher
Doi

Abstract

Mitophagy is the elimination of damaged mitochondria by the autophagosome regulated by the ubiquitin ligase, parkin and the kinase PINK1; a genome-wide RNAi screen with high-content microscopy has identified new genes that have an upstream role in parkin translocation to the mitochondria

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ZENODO

oai:zenodo.org:1233326

Last time updated on 16/06/2018

This paper was published in ZENODO.

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