Major Susceptibility Locus for Prostate Cancer on Chromosome 1 Suggested by a Genome-Wide Search

Smith, J. R.; Freije, D.; Carpten, J. D.; Gronberg, H.; Xu, J.; Isaacs, S. D.; Brownstein, M. J.; Bova, G. S.; Guo, H.; Bujnovszky, P.; Nusskern, D. R.; Damber, J.-E.; Bergh, A.; Emanuelsson, M.; Kallioniemi, O. P.; Walker-Daniels, J.; Bailey-Wilson, J. E.; Beaty, T. H.; Meyers, D. A.; Walsh, P. C.; Collins, F. S.; Trent, J. M.; Isaacs, W. B.

research article

Major Susceptibility Locus for Prostate Cancer on Chromosome 1 Suggested by a Genome-Wide Search

Authors: J. R. Smith
D. Freije
J. D. Carpten
H. Gronberg
J. Xu
S. D. Isaacs
M. J. Brownstein
G. S. Bova
H. Guo
P. Bujnovszky
D. R. Nusskern
J.-E. Damber
A. Bergh
M. Emanuelsson
O. P. Kallioniemi
J. Walker-Daniels
J. E. Bailey-Wilson
T. H. Beaty
D. A. Meyers
P. C. Walsh
F. S. Collins
J. M. Trent
W. B. Isaacs
Publication date: 22 November 1996
Publisher
Doi

Abstract

Despite its high prevalence, very little is known regarding genetic predisposition to prostate cancer. A genome-wide scan performed in 66 high-risk prostate cancer families has provided evidence of linkage to the long arm of chromosome 1 (1q24-25). Analysis of an additional set of 25 North American and Swedish families with markers in this region resulted in significant evidence of linkage in the combined set of 91 families. The data provide strong evidence of a major prostate cancer susceptibility locus on chromosome 1

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ZENODO

oai:zenodo.org:1231086

Last time updated on 16/06/2018

This paper was published in ZENODO.

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