Formal Cycloaddition of Disubstituted Ketenes with 2-Oxoaldehydes Catalyzed by Chiral N-Heterocyclic Carbenes
Abstract
Chiral N-hetereocyclic carbenes were found to be efficient catalysts for the formal [2 + 2] cycloaddition reactions of alkyl(aryl)ketenes with 2-oxoaldehydes to afford β-lactones with α-quaternary-β-tertiary stereocenters in high yields with good diastereoselectivities and excellent enantioselectivities (up to 99% ee). Both alkyl(aryl)ketenes and diarylketene worked well in this reaction- Dataset
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- Biochemistry
- Molecular Biology
- Evolutionary Biology
- Sociology
- Developmental Biology
- Cancer
- Environmental Sciences not elsewhere classified
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- ee
- stereocenter
- Formal Cycloaddition
- Disubstituted Ketenes
- cycloaddition
- Oxoaldehyde
- oxoaldehyde
- diastereoselectivitie
- diarylketene
- lactone
- Carbene
- Chiral
- enantioselectivitie
- carbene
- Catalyzed
- alkyl
- yield
- quaternary
- catalyst
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Last time updated on 16/03/2018
This paper was published in The Francis Crick Institute.
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