textjournal article
Catalytic, Asymmetric Michael Reactions of Cyclic Diketones with β,γ-Unsaturated α-Ketoesters
Abstract
Newly synthesized cinchona alkaloid-derived pyrimidines function as effective asymmetric catalysts for the Michael reaction between cyclic diketones and β,γ-unsaturated α-ketoesters. The reactions of electrophiles with either aryl or alkyl γ-substituents give 64−99% yields and 94−99% ee- Text
- Journal contribution
- Biochemistry
- Medicine
- Cell Biology
- Physiology
- Sociology
- Immunology
- Developmental Biology
- Mental Health
- Infectious Diseases
- Virology
- Computational Biology
- electrophile
- Catalytic
- ee
- Cyclic Diketones
- ketoester
- Asymmetric Michael Reactions
- pyrimidine
- cinchona
- cyclic diketones
- function
- substituent
- catalyst
- Michael reaction
- alkyl
- Ketoester
- yield
- aryl
- Unsaturated
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Last time updated on 16/03/2018
This paper was published in The Francis Crick Institute.
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