textjournal article
Diastereoselective Alkylations of a Protected Cysteinesulfenate
Abstract
To further understand stereoselection in the alkylation of sulfenate anions, a protected cysteinesulfenate was generated in THF solution at low temperature. Introduction of a reactive alkylating agent brings about a cysteinyl sulfoxide in 51−75% yield, with diastereomeric ratios at the sulfinyl group ranging from 83:17 to 95:5. An internally complexed lithium counterion is proposed to account for the stereoselectivity- Text
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- Introduction
- stereoselection
- cysteinesulfenate
- diastereomeric ratios
- Diastereoselective Alkylations
- sulfinyl group
- THF solution
- cysteinyl sulfoxide
- alkylation
- complexed lithium counterion
- reactive alkylating agent
- stereoselectivity
- sulfenate anions
- Protected CysteinesulfenateTo
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Last time updated on 16/03/2018
This paper was published in The Francis Crick Institute.
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