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Bioactive sesquiterpenoids and steroids from the resinous exudates of <i>Commiphora myrrha</i>

By Chi-Yu Ge (4955119) and Jun-Li Zhang (4955122)


<p>Chemical investigation of the resinous exudates of <i>Commiphora myrrha</i> has led to the isolation of four sesquiterpenes (<b>1a</b>/<b>1b</b>, <b>2</b>, and <b>3</b>), including one pair of new sesquiterpene enantiomers (<b>1a</b>/<b>1b</b>), one new racemic mixture <b>2</b>, and two steroids (<b>4</b> and <b>5</b>). Their structures were elucidated by spectroscopic analysis, and the absolute configurations of <b>1a</b>/<b>1b</b> were determined by CD analysis. The antimigratory potential of compounds <b>1</b>–<b>5</b> were evaluated and compound <b>3</b> was found to inhibit human hepatocellular liver carcinoma HepG2 cell migration in dose-dependent manner.</p

Topics: Biochemistry, Cell Biology, Pharmacology, Ecology, Inorganic Chemistry, Science Policy, Hematology, Space Science, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Commiphora myrrha, sesquiterpene, steroids, antimigratory activity
Year: 2018
DOI identifier: 10.6084/m9.figshare.5977369.v1
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Provided by: FigShare
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