Bioactive sesquiterpenoids and steroids from the resinous exudates of <i>Commiphora myrrha</i>

Abstract

<p>Chemical investigation of the resinous exudates of <i>Commiphora myrrha</i> has led to the isolation of four sesquiterpenes (<b>1a</b>/<b>1b</b>, <b>2</b>, and <b>3</b>), including one pair of new sesquiterpene enantiomers (<b>1a</b>/<b>1b</b>), one new racemic mixture <b>2</b>, and two steroids (<b>4</b> and <b>5</b>). Their structures were elucidated by spectroscopic analysis, and the absolute configurations of <b>1a</b>/<b>1b</b> were determined by CD analysis. The antimigratory potential of compounds <b>1</b>–<b>5</b> were evaluated and compound <b>3</b> was found to inhibit human hepatocellular liver carcinoma HepG2 cell migration in dose-dependent manner.</p