Altered metabolism of growth hormone receptor mutant mice: a combined NMR metabonomics and microarray study

Schirra, Horst Joachim; Anderson, Cameron G.; Wilson, William J.; Kerr, Linda; Craik, David J.; Waters, Michael J.; Lichanska, Agnieszka M.

journal article

oai:espace.library.uq.edu.au:UQ:165011

Altered metabolism of growth hormone receptor mutant mice: a combined NMR metabonomics and microarray study

Authors: Horst Joachim Schirra
Cameron G. Anderson
William J. Wilson
Linda Kerr
David J. Craik
Michael J. Waters
Agnieszka M. Lichanska
Publication date: 23 July 2008
Publisher: 'Public Library of Science (PLoS)'
Doi

Abstract

Growth hormone is an important regulator of post-natal growth and metabolism. We have investigated the metabolic consequences of altered growth hormone signaling in mutant mice that have truncations at position 569 and 391 of the intracellular domain of the growth hormone receptor, and thus exhibit either low (around 30% maximum) or no growth hormone-dependent STATS signaling respectively. These mutants result in altered liver metabolism, obesity and insulin resistance

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Last time updated on 30/08/2013

This paper was published in UQ eSpace (University of Queensland).

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