Synthesis of Five‑,
Six‑, and Seven-Membered
1,3- and 1,4-Heterocyclic Compounds via Intramolecular Hydroalkoxylation/Hydrothioalkoxylation
of Alkenols/Thioalkenols
- Publication date
- 2015
- Publisher
Abstract
Intramolecular
hydroalkoxylation/hydrothioalkoxylation of nitrogen-tethered
alkenes and alcohols/thiols mediated by boron trifluoride etherate
leads to five-membered thiazolidine, six-membered 1,4-oxazines (morpholines)
and tetrahydro-2<i>H</i>-1,4-thiazines (thiomorpholines),
and seven-membered 1,4-oxazepanes in good yields