Smart Polymeric Nanoparticles for Cancer Gene Delivery
- Publication date
- 2015
- Publisher
Abstract
The massive amount of human genetic
information already available
has accelerated the identification of target genes, making gene and
nucleic acid therapy the next generation of medicine. Nanoparticle
(NP)-based anticancer gene therapy treatment has received significant
interest in this evolving field. Recent advances in vector technology
have improved gene transfection efficiencies of nonviral vectors to
a level similar to viruses. This review serves as an introduction
to surface modifications of NPs based on polymeric structural improvements
and target moieties. A discussion regarding the future perspective
of multifunctional NPs in cancer therapy is also included