A new sesquiterpene lactone from yacon leaves

Abstract

<p>The chemical constituents of 60% EtOH extract of yacon leaves were separated to yield a new compound, together with four known compounds, which were isolated for the first time from yacon. The new compound was characterised and named as chlorodalin (<b>1</b>) on the basis of NMR (1D and 2D), HR-MS and other spectral methods. The cytotoxic activities of <b>1</b>–<b>5</b> were evaluated on two human tumour cell lines and the new compound showed significant cytotoxic activity.</p