Mode of inheritance of deficient corpus callosum in mice

Abstract

Many mice of the Inbred strain BALB/cCF have deficient corpus callosum, and a few of them have total absence of this large forebrain commissure. Reciprocal F1 hybrid crosses with the inbred strains A/J, C57BL/6J, and DBA/2J revealed that Inheritance of the defect Is completely recessive. Reciprocal backcrosses to BALB/cCF revealed that Inheritance is not attributable to a single Mendelian locus with the same degree of pens-trance as In the parent strain. The ac locus has not been rediscovered, Instead, there Is good reason to withdraw ac from current listings of Mendelian loci in the mouse