THE STUDY OF ANTIMICROBIAL ACTIVITY OF COMBINATIONS OF FOSFOMYCIN WITH CEFEPIME AND FOSFOMYCIN WITH TIENAM IN RESPECT POLYANTIBIOTIC-RESISTANT STRAINS OF ENTEROBACTERIA

Abstract

Introduction. The rapid decrease in sensitivity of pathogens of septic infections to antimicrobial agents has led to significant difficulties in the treatment of antibioticresistant infections. One solution of this problem is the method of combining of antimicrobial medications from different pharmacological groups. Antimicrobial synergy resulting from antibiotic combination therapy is often important in the treatment of serious bacterial infections. The aim of the study is investigation of combined antimicrobial action of fosfomycin with cefepim and fosfomycin with tienam in respect polyantibiotic-resistent strains of enterobacteria. Materials and methods. The polyantibioticresistant strains used in this study were isolated from patients hospitalised in the Hospital of Kharkov. The study of combinations of antibiotics efficacy was carried out by determining the minimum inhibitory concentrations using routine in vitro “checkerboard” method. Results and discussion. Calculation of the fraction inhibitory index showed that the combination of fosfomycin with cefepime demonstrated synergistic inhibitory activity against 71,43 % of enterobacteria strains tested; combination of fosfomycin with tienam result in summation or indifferent effect against 71,43 % polyantibioticresistant strains of enterobacteria. Conclusion. Thereby combination of fosfomycin with cefepime may be considered as synergistic and perspective for further experimental in vivo studies and studies of their clinical effectiveness against polyantibioticresistant strains of enterobacteria – causative agents of pyoinflammatory diseases