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Anti-inflammatory properties of cryptolepine.

By O.A. Olajide, A.A. Ajayi and Colin W. Wright

Abstract

noCryptolepine is the major alkaloid of the West African shrub, Cryptolepis sanguinolenta. Cryptolepine has\ud been shown to inhibit nitric oxide production, and DNA binding of Nuclear Factor-kappa B following\ud inflammatory stimuli in vitro. In order to validate the anti-inflammatory property of this compound in vivo,\ud we investigated its effects on a number of animal models of inflammation. Cryptolepine (10¿40 mg/kg i.p.)\ud produced significant dose-dependent inhibition of the carrageenan-induced rat paw oedema, and carrageenaninduced\ud pleurisy in rats. These effects were compared with those of the non-steroidal anti-inflammatory drug\ud indomethacin (10 mg/kg). At doses of 10¿40 mg/kg i.p., cryptolepine inhibited lipopolysaccharide (LPS)-induced\ud microvascular permeability in mice in a dose-related fashion. Oral administration of up to 40 mg/kg of the\ud compound for four consecutive days did not induce gastric lesion formation in rats. Analgesic activity was also\ud exhibited by cryptolepine through a dose-related (10¿40 mg/kg i.p.) inhibition of writhing induced by i.p.\ud administration of acetic acid in mice. The results of this study reveal that cryptolepine possesses in vivo\ud anti-inflammatory activity.Copyright © 2009 John Wiley & Sons, Ltd

Topics: Cryptolepine, Cryptolepis sanguinolenta, Anti-inflammatory properties, Analgesic
Publisher: John Wiley & Sons
Year: 2010
DOI identifier: 10.1002/ptr.2794
OAI identifier: oai:bradscholars.brad.ac.uk:10454/4536
Provided by: Bradford Scholars
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