The software solution “Imunolog”, presented in this paper, is developed after winning international project between University Hospital Alexandrovska, New Bulgarian University and Barcelona Medical University.\ud The fundamental initiative is to localize the main predispositions for this disease based on the statistic data from Bulgarian patients, the relationship between treatment and following manifestations of the disease, sequence of results from a concrete therapy and human body systems reactions and adaptation. \ud In our country there are no investigations and results, regardless of the enormous database of paper epicrysis, visits and anamnesis. \ud Systemic lupus erythematosus (SLE) is a widespread disease with unknown cause, which attacks person's immune system and injures the body's own organs and tissues. \ud We have addressed this problem and devised a software system for assessing both current lupus disease activity and changes in that activity since the patient`s last visit. Imunolog©® is retrospective database with strictly defined purpose objectives – to explore causes, treatment schemes, manifestations and reactions of all available patients in Bulgaria since 1960. It is a result of won international project between University Hospital Alexandrovska, New Bulgarian University and Barcelona Medical University. \u
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