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Is adiponectin implicated in venous thromboembolism?

By J. A. Fernández, N. M. Pecheniuk, H. Deguchi, D. J. Elias and J. H. Griffin


In summary, these results imply that the relationship of adiponectin with lipoproteins is more complex than previously predicted using other methods of lipoprotein fractionation. Higher correlation of adiponectin was shown with large lipoprotein particle size, independent of the apolipoprotein content. Given the small population studied, we could not assess the influence of mild risk factors for venous thrombosis, such as obesity, on the analysis of the results. Thus, we can only state that adiponectin levels appear not to be a strong risk factor for VTE. It is possible that adiponectin deficiency may contribute indirectly to the etiology of VTE by enhancing the inflammatory state. © 2006 International Society on Thrombosis and Haemostasis

Topics: adiponectin, apolipoprotein B, high density lipoprotein, low density lipoprotein, triacylglycerol, adipocyte, artery thrombosis, article, atherogenesis, atherosclerosis, atherosclerotic plaque, body mass, cardiovascular disease, cardiovascular risk, coronary artery disease, correlation analysis, correlation coefficient, deep vein thrombosis, disease association, enzyme linked immunosorbent assay, hormone action, hormone blood level, hormone deficiency, human, insulin resistance, insulin sensitivity, knockout mouse, lipid analysis, lipid oxidation, lipoprotein blood level, nonhuman, obesity, particle size, pathogenesis, prediction, prevalence, priority journal, protein expression, proton nuclear magnetic resonance, risk factor, sex difference, thrombogenesis, transgenic mouse, triacylglycerol blood level, venous thromboembolism, Animals, Body Mass Index, Case-Control Studies, Enzyme-Linked Immunosorbent Assay, Humans, Magnetic Resonance Spectroscopy, Metabolic Syndrome X, Mice, Mice, Transgenic, Thromboembolism, OAVJ
Publisher: Blackwell Publishing
Year: 2006
DOI identifier: 10.1111/jth.2006.4.issue-5/issuetoc
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