Antiviral activity of glycyrrhizic acid derivatives against SARS-coronavirus.

Hoever, Gerold; Baltina, Lidia; Michaelis, Martin; Kondratenko, Rimma; Baltina, Lia; Tolstikov, Genrich A; Doerr, Hans Wilhelm; Cinatl, Jindrich

oai:kar.kent.ac.uk:34111

Antiviral activity of glycyrrhizic acid derivatives against SARS-coronavirus.

Authors: Gerold Hoever
Lidia Baltina
Martin Michaelis
Rimma Kondratenko
Lia Baltina
Genrich A Tolstikov
Hans Wilhelm Doerr
Jindrich Cinatl
Publication date: 1 February 2005
Publisher: American Chemical Society
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Abstract

Glycyrrhizin (GL) was shown to inhibit SARS-coronavirus (SARS-CoV) replication in vitro. Here the anti-SARS-CoV activity of 15 GL derivatives was tested. The introduction of 2-acetamido-beta-d-glucopyranosylamine into the glycoside chain of GL resulted in 10-fold increased anti-SARS-CoV activity compared to GL. Amides of GL and conjugates of GL with two amino acid residues and a free 30-COOH function presented up to 70-fold increased activity against SARS-CoV but also increased cytotoxicity resulting in decreased selectivity index

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oai:kar.kent.ac.uk:34111

Last time updated on 06/06/2013

This paper was published in Kent Academic Repository.

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