Prosthetic joint infection. A relevant public health issue.

Prosthetic joint infection (PJI) is a common complication of the knee and hip arthroplasty and represents a huge challenge for physicians. PJI raises serious social, economic and clinical concerns in the public health that need a comprehensive approach to better focus on proven strategies for disease prevention and treatment. History and clinical signs on joint site are useful means for suspecting PJI that need to be confirmed through major and minor diagnostic criteria. The pathogen isolation and the resulting antibiogram are crucial to guide the correct antibiotic strategy and together with surgical treatment (prosthesis revision and spacer implantation) represent the cornerstones to eradicate the infection before attempting a new arthroplasty. External fixator with removal of the spacer may be an option before performing a new arthroplasty when the infection does not heal. Arthrodesis may also be considered if the arthroplasty is contraindicated. Limb amputation is the last chance when pathogen eradication failed and might lead to life-threatening situations

Look how smart I am!: Only narcissistic admiration is associated with inflated reports of intelligence

Abstract Individuals with high grandiose narcissism tend to think they are extraordinarily intelligent, and these views determine their psychological well-being. In the current research, we investigated how two aspects of grandiose narcissism—admiration and rivalry—are associated with objective intelligence, subjective intelligence, and intelligence-related beliefs. We expected that only narcissistic admiration, which reflects the agentic aspect of grandiose narcissism, would be associated with subjective intelligence as the latter is regarded as a prototypical agentic attribute. In Study 1 (N = 311) narcissism (i.e., admiration and rivalry) was uncorrelated with objective intelligence but admiration was related to inflated self-reported intelligence as well as global life satisfaction and domain-specific intelligence satisfaction. Furthermore, intelligence-related beliefs mediated the link between admiration and life satisfaction. In Study 2 (N = 211), consistent with the predictions, people with high admiration perceived intelligence as an important way to gain popularity. By contrast, individuals scoring high on rivalry perceived intelligence as a factor influencing social status and having low importance in interpersonal relations. Our findings suggest that intelligence is a key characteristic only for those narcissists who score high on the admiration dimension, but not the rivalry dimension

Generation of two human iPSC lines, FINCBi002-A and FINCBi003-A, carrying heteroplasmic macrodeletion of mitochondrial DNA causing Pearson's syndrome

Pearson marrow pancreas syndrome (PMPS) is a sporadic mitochondrial disease, resulting from the clonal expansion of a mutated mitochondrial DNA (mtDNA) molecule bearing a macro-deletion, and therefore missing essential genetic information. PMPS is characterized by the presence of deleted (Δ) mtDNA that co-exist with the presence of a variable amount of wild-type mtDNA, a condition termed heteroplasmy. All tissues of the affected individual, including the haemopoietic system and the post-mitotic, highly specialized tissues (brain, skeletal muscle, and heart) contain the large-scale mtDNA deletion in variable amount. We generated human induced pluripotent stem cells (hiPSCs) from two PMPS patients, carrying different type of large-scale deletion

Epidemiology of Soft Tissue Sarcoma and Bone Sarcoma inItaly: Analysis of Data from 15 Population-Based Cancer Registries

Sarcomas are a heterogeneous group of rare cancers of mesenchymal origin. In this study, we provide updated, world age-standardised incidence rate (ASR) and European age-standardised incidence rate for malignant soft tissue sarcoma (ICD-O-3 topographic code C47–C49) and bone sarcoma (C40, C41) in Italy, by area (north, centre, and south) and by cancer registry. We also assess morphology in relation to site and area and assess metastases at diagnosis. We analysed 1,112 cases, with incidence 2009–2012, provided by 15 cancer registries (CRs) affiliated to the Association of Italian Cancer Registries (AIRTUM). Overall, ASR was 1.7/100,000/year for soft tissue sarcoma and 0.7 for bone sarcoma. Central Italy had the highest (2.4) ASR and south Italy had the lowest (1.6) ASR for soft tissue sarcoma. Central Italy had the highest (1.1) ASR and north Italy had the lowest (0.7) ASR for bone sarcoma. By CR, ASRs ranged from 1.1 to 2.6 for soft tissue sarcoma and from 0 to 1.4 for bone sarcoma. The most frequent soft tissue sarcomas were sarcoma not otherwise specified (NOS) (29.4%) and liposarcoma (22.2%); the most common bone sarcoma was chondrosarcoma (37.6%). Soft tissue sarcomas occurred most frequently (35.6%) in lower limb connective tissue; bone sarcomas arose mainly (68.8%) in long bones. The frequencies of morphologies arising at different sites varied considerably by Italian area; for example, 20% of hemangiosarcomas occurred in the head and neck in south Italy with 17% at this site in the centre and 6% in the north. For soft tissue sarcoma, the highest ASRs of 2.6 and 2.4 contrast with the lowest ASRs 1.1 and 1.3, suggesting high-risk hot spots that deserve further investigation. The marked variations in morphology distribution with site and geography suggest geographic variation in risk factors that may also repay further investigation particularly since sarcoma etiology is poorly understood

Alternative fining of Sangiovese wine: effect on phenolic substances and sensory characteristics

n/

Sociolinguistic Aspects and Language Contact: Evidence from Francoprovençal of Apulia

Abstract The aim of this paper is to investigate two Francoprovençal speaking communities in the Italian region of Apulia, Faeto and Celle di St. Vito. Despite the regional neighborhood of the two towns, and their common isolation from other Francoprovençal speaking communities, their sociolinguistic conditions are deeply different. They differ in reference to the functional distribution of the languages of the repertoire and speakers' language uses, and in reference to the degree of 'permeability' of Francoprovençal varieties towards Italian and its dialects. The repertoire composition and the relationship between the codes have a key role both for minority language maintenance and for language contact processes. In this perspective, I analyse some language contact phenomena in a sample of speakers discourse. I report correlations between the choice of different code-mixing strategies and three sociolinguistic variables (age, sex and village), but not with occupation

Glycated Albumin, An Early Biomarker of Several Pathologies

The role of glycated albumin is determinant for early diagnosis in several pathologies. Obviously, it is with glycated hemoglobin elective for Diabetes diagnosis but the ratio albumin glycated and hemoglobin glycated could support the in vitro diagnosis in several pathologies of CNS such as Parkinson Alzheimer diseases and Epilepsy

is adherence to treatment influenced by the ability to use inhaled devices in patients with copd correctly

n/

Internet Cognitive Behavioral Therapy With or Without Face-to-Face Psychotherapy: A 12-Weeks Clinical Trial of Patients With Depression

n/

Electric Power Distribution System Reliability Evaluation Considering the Impact of Weather on Component Failure and Pre-Arranged Maintenance

n/