Bleed treatment with eptacog beta (rFVIIa) results in a low incidence of rebleeding in adult and adolescent patients with haemophilia A or B with inhibitors.

INTRODUCTION: Eptacog beta is a novel human recombinant FVIIa approved for use in the United States, European Union, United Kingdom and Mexico for the treatment and control of bleeding in patients with haemophilia A or B with inhibitors (≥12 years). It is also indicated for perioperative care in the same patient population in Europe and the United Kingdom. AIM: To assess the incidence of rebleeding and review treatment outcomes in subjects with haemophilia with inhibitors enrolled in the phase 3 PERSEPT 1 clinical trial. METHODS: To treat mild/moderate bleeding episodes (BEs), subjects administered an initial 75 or 225µg/kg dose of eptacog beta, followed (if necessary) by additional 75µg/kg doses at predefined intervals until bleed control. This analysis used subject-reported rebleeding to determine a rebleeding incidence for the first 24 h. Rebleeding through later timepoints was an exploratory, intention-to-treat analysis of bleed treatment data. RESULTS: Four hundred and sixty-five BEs were analysed. Through 24 h, the proportion of rebleeds was 0% (initial 75µg/kg dose) and 0.5% (initial 225µg/kg dose). Through 48 h, the proportion of rebleeds was 3.2% (75µg/kg initial dose) and 5.6% (225µg/kg initial dose); the difference between initial dose strategies was not statistically significant. The majority of rebleeds were controlled with a single dose of eptacog beta and no subject who treated a rebleed required hospitalization. CONCLUSION: Subjects with haemophilia with inhibitors who used eptacog beta to treat mild/moderate BEs experienced a low incidence of rebleeding. Rebleeds that did occur were effectively controlled with eptacog beta (median, one dose) without the need for hospitalization

Spark-ablated metal nanoparticle catalysts supported on TiO2 for CO2 methanation

We report the first synthesis of a powdery heterogeneous catalyst using spark ablation technology.1 A spark nanoparticle generator is modified to allow a direct deposition onto pulverulent materials. The concept relies on the aerosolization of a powder, which is gas-transported and injected in the path of metal nanoparticle formation. Herein, TiO2 powder is used as the catalyst support, while Ni or Ru electrodes are used to generate Ni or Ru nanoparticles as the active phase. The resulting Ni/TiO2 and Ru/TiO2 catalysts are readily active in the hydrogenation of CO2 to CH4

Rédaction de brèves descriptions de manuscrits dans la base de données Handschriftencensus

https://handschriftencensus.de/16880 https://handschriftencensus.de/263

Early Detection, Diagnosis, Prevention, and Treatment of Infection to Avoid Sepsis and Septic Shock in Severely Burned Patients: A Narrative Review.

The early detection, diagnosis, anticipation, and therapy of infections to prevent sepsis and septic shock remain significant challenges in cases of grave burns. This narrative review explores various tools for early infection detection, including emerging biomarkers, the American Burn Association's clinical criteria, and traditional blood parameters. A comparative study of the American Burn Association, Mann-Salinas, and Sepsis-3 criteria highlights the superior early detection capabilities of the Sepsis-3 criteria. However, the authors recommend that sepsis should be prospectively evaluated, identified, and classified by the intensive care group, rather than by relying solely on retrospective items, though the latter may still be necessary in certain cases. Advances in biomarker identification, including polymerase chain reaction (PCR) and gene expression (mRNA) profiling, offer diagnostic advantages over current methods, enabling early detection within 4 to 6 h of intensive care unit admission. Mass spectrometry also shows promise for the rapid determination of bacteria, yeast, and fungi based on bacteria protein profiles. Source control remains crucial, and the use of antibacterial topical agents has significantly improved the survival rates of severely burned patients. However, antibiotic selection must be made judiciously to avoid resistance. Despite these advancements, significant progress is still needed to improve the rapid identification, actual presence, prevention, and therapy of infections to reduce the incidence of sepsis and septic shock in this patient subgroup

Control, characterization, and validation of the Efficient Lockable Spring Ankle (ELSA) prosthesis

The majority of ankle prostheses available today are passive, lacking the net positive energy output of biological ankles, which tends to lead to asymmetric gait and related health issues. Recent advancements in powered prostheses tend to mimic ankle joint behavior, but design constraints like weight, size, and energy efficiency, along with challenges in performance evaluation and control development, remain significant. This research focuses on the ELSA prosthesis, a compact and lightweight powered ankle. The first objective of this thesis was to characterize the device specifically examining its power, torque, energy efficiency, and related metrics. Next aims focused on developing and validating a high-level controller for autonomous task detection, as well as evaluating the device versatility across various functions. To accomplish these objectives, we carried out both bench validation and experimental trials with prosthesis users, testing ELSA under a range of conditions. Overall, this thesis underscores ELSA's potential to replicate ankle dynamics, providing control strategies for daily life adaptability, while identifying areas for improvement and future development.(FSA - Sciences de l'ingénieur) -- UCL, 202

Conical Free Disposal Hull estimators of directional distances and Luenberger productivity indices for general technologies

Directional distances are a popular tool in productivity and efficiency analysis due to their versatility in evaluating the distance of Decision Making Units (DMU) to the efficient frontier of the production set. The theoretical and statistical properties of these measures are well-established in various contexts. However, the measurement of directional distances to the cone spanned by the attainable set has not yet been explored. This cone is necessary to define the Luenberger indices for general technologies. This paper aims to fill this gap by presenting a method for defining and estimating directional distances to this cone, applicable to general technologies without imposing convexity. We also discuss the statistical properties of these measures, enabling us to measure distances to non-convex attainable sets under Constant Returns to Scale (CRS), as well as measure and estimate Luenberger productivity indices and their decompositions for general technologies. In addition, we provide a detailed description of how to make inferences on these indices. Finally, we offer simulated data and a practical example of inference on Luenberger productivity indices and their decompositions using a well-known real data set

Les missions pastorales confiées et la formation exigée des candidats et candidates rencontrent-elles leurs quêtes spirituelles ? Analyse des réponses à une enquête

Sur base d'une enquête menée auprès des alumni et étudiants et étudiantes des différents certificats en théologie pastorale, la communication analysera si les missions pastorales qui leur sont confiées rencontrent leurs quêtes spirituelles

Health insurance Convention for Severe Pediatric Feeding Disorder: A 15-Year Review of Multidisciplinary Follow-up for Children with Enteral Nutrition

Background The convention between the Health Insurance Committee and the Belgian multidisciplinary teams (7 since 2009, 9 since 2021) allows to establish a therapeutic plan and follow-up for children (0 to 12 years) with severe pediatric feeding disorder (PFD) requiring artificial nutrition in present or past. These children present complex underlying conditions (except severe neurological conditions), inadequate feeding skills, nutritional and psychosocial dysfunctions. The aim is to support the child and the family in achieving age-appropriate oral feeding pattern. Methods Data were collected from the annual reports of all participating centers. Records were as follows: number of children, medical aspects including underlying conditions and type of oral feeding disorder, nutritional, psychosocial aspects, therapeutic plans and the overall cost of the convention. Indicators included the percentage of children who weaned off enteral nutrition, changes in eating behavior and amount of oral food intake. Results Between 2009 and 2023, the total number of patients increased from 163 to 317 per year (increase of 12.9% per year). The underlying conditions were gastrointestinal (28.3%), genetic (27.5%), cardiac (14.5%), respiratory (9.1%), oro-facial (9.5%), and others (20.6%). These conditions may overlap. Prematurity was persistently present in 25% of cases. Over the last three years, medical conditions were the predominant cause (61%), followed by inadequate feeding skills (48%), nutritional deficits (46%), and psychosocial problems (31%). The therapeutic plan is tailored to each patient. It includes specialized medical care (66%), nursing (35%), and dietary (72%) care, oral sensorimotor therapy (57%), global body therapy (33%), appetite interventions (43%), psychological support (29%), behavioral therapies (30%), and parental guidance (55%). Nutritional support was weaned off on an average of 40.5% of cases per year. Oral feeding autonomy was achieved in 92% of cases on average per year. Evaluation of the convention’s costs showed an annual increase of 12%, proportionally to the increase in patients. Conclusion The increase in patients number reflects the evolution of tertiary care for all complex conditions. The individualized plan for each patient based on the multidisciplinary approach has proven effective. It is important to support ongoing follow-up and management downstream, involving various paramedical professionals engaged in the treatment of PFD

Health insurance Convention for Severe Pediatric Feeding Disorder: A 15-Year Review of Multidisciplinary Follow-up for Children with Enteral Nutrition

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