Transportation of payload using quadcopters under physical constraint with human in the loop

by Pratik PrajapatiM.Tech

Effect of microstructure on stress�strain and pore-pressure response of sabarmati sand under the influence of mica

Micaceous soil is believed to be detrimental for civil engineering constructions due to the effect of high compressibility, low compacted density and low shear strength. Individual mica particle has numerous intact mica flakes foliated over each other making it flexible upon loading and rebound upon unloading due to its low hardness and resilient nature. Hence, micaceous soils with mica content more than 10% are considered undesirable for highway pavements, embankments and railway track constructions. When platy mica particles are sufficiently numerous to interact with spherical sand particles, bridging and ordering phenomena are augmented within the soil mass creating unique sand-mica particle orientation (MS microstructure) unlike sand-sand particle orientation (PS microstructure). The current experimental research was conducted to evaluate the variation in stress�strain, pore pressure and effective stress path response of Sabarmati sand under the influence of mica (sand with 30% mica and pure sand) with MS and PS microstructure respectively. Effect of particle crushing on stress�strain and pore pressure response was also studied on Sabarmati sand with MS and PS microstructure. Distinctive macroscopic response was observed in Sabarmati sand with MS microstructure under the influence of mica as well as mica particle crushing.by P. Seethalakshmi and Ajanta Sacha

Experimental study on static and cyclic liquefaction on cohesionless chang dam soil

by Majid Hussain and Ajanta Sacha

Tracing the GSAP-APP C-99 interaction site in the β-amyloid pathway leading to Alzheimer's disease

Gamma secretase activating protein (GSAP) present in β-amyloid pathway orchestrates the formation of β-amyloid plaques by γ-secretase activation and is an emerging therapeutic target for the treatment of Alzheimer’s disease. It forms a ternary complex with γ secretase and APP C-99. However, there are limited reports for the interaction of APP C-99 with GSAP. Here, we report the characterization of purified maltose binding protein tagged human GSAP and its interaction with synthetic APP C-99 peptide fragments (712IATVIVITLVMLKKQ727 (712IQ727), 719TLVMLKKKQYTSIHHGVVEVDAAVT743 (719TT743) 734GVVEVDAAVTPEERHLSKMQQNGY757 (734GY757), and 746ERHLSKMQQNGYENPTYKFFEQMQN770 (746EN770)). The results emphasize the selective interaction of peptide (719TT743) with MBP-GSAP with a dissociation constant of 0.136 µM. Further, computational modeling of the GSAP - 719TT743 complex finds an optimal bound pose of 719TT743 within an extended groove on the surface of GSAP. The preliminary results highlight the interaction between the two major proteins in the plausible ternary complex; APP C-99-GSAP- γ secretase. It paves a futuristic path to investigate the GSAP- APP C-99 binding in detail and accentuate the role of GSAP in the β-amyloid pathway.by Deekshi Angira, Rupesh Chikhale, Kapilkumar Mehta, Richard A. Bryce and Vijay Thiruvenkata

On the parameterized complexity of edge-linked paths

by Neeldhara Misra, Fahad Panolan and Saket Saurab

NICSPol: a near infrared polarimeter for the 1.2 m telescope at Mount Abu infrared observatory

NICSPol is a near infrared imaging polarimeter developed for the Near Infrared Camera and Spectrograph (NICS), one of the back end instruments of the 1.2 m Cassegrain telescope at the Mount Abu Infrared Observatory (MIRO), India. The polarimeter consists of a rotating wire grid polarizer which is mounted between the telescope optics and NICS. The polarimetric observations are carried out by rotating the polarizer using a motorized mechanism to determine the Stokes parameters, which are then converted into the polarization fraction and polarization angle. Here we report the details of the instrument and the results of observations of IR polarimetric standards. A set of polarized and unpolarized standards were observed using NICSPol over J, H and Ks bands covering 0.8 to 2.5 micro m. The observations of polarized standards using NICSPol show that, NICSPol can constrain polarization within ~1% for sources brighter than ~16 magnitude in JHKs bands. NICSPol is a general purpose instrument which could be used to study variety of astrophysical sources such as AGNs, Pulsars, XRBs, Supernovae, star forming regions etc. With few NIR polarimeters available world-wide so far, NICSPol would be the first imaging NIR polarimeter in India.by Esakkiappan Aarthy, Archita Rai, Shashikiran Ganesh and Santosh V. Vadawal

Read-decoupled radiation hardened RD-DICE SRAM cell for low-power space applications

by Mili Lavania, Neelam Surana, Ishant Anand and Joycee Meki

Arsenic mobility and potential co-leaching of fluoride from the sediments of three tributaries of the upper Brahmaputra floodplain, Lakhimpur, Assam, India

A sequential extraction procedure (SEP), batch desorption experiments and the concept of partition coefficient were applied on seven sediment samples from the Subansiri-Dikrong-Ranganadi River System (SDRS), a subset of the upper Brahmaputra floodplain (BFP), to understand leaching of arsenic (As) and fluoride (F−). Sediment samples were collected during monsoon and post-monsoon seasons from each of three river banks to distinguish the effect of annual cyclic flooding events on As content and mobilization. SEP revealed that the readily leachable chemisorbed As phase and amorphous Fe (hydr)oxides were the principal contributors to mobilized As during the monsoon season. Constant flushing of the rivers removed most of the physisorbed and chemisorbed As during the monsoon. A submerged anoxic condition toward late monsoon resulted in Fe (hydr)oxides becoming the dominant source of removable As during the post-monsoon season. Iron in the sediments was positively correlated with F− during both monsoon and post-monsoon seasons. This suggests that Fe (hydr)oxides are a host for F− and a correlation between reductive hydrolysis and F−. Removal of Fe (hydr)oxides from the sediments significantly reduced As retention/leaching capacity. Arsenic desorption was especially high from raw sediments of the Ranganadi River owing to the fact that it had the highest amount of As associated with Fe (hydr)oxides, which falls sharply in the post-monsoon season due to a prolonged submerged state leading to reductive dissolution. However, as leached F− is being constantly flushed out by the SDRS, F− contamination may not pose a problem in the current or futuristic scenarios.by Arbind Kumar Patel, Nilotpal Das, Ritusmita Goswami and Manish Kuma

Hydrazide‐hydrazone small molecules as AIEgens: illuminating mitochondria in Cancer cells

Aggregation induced emission probes (AIEgens) have gained lots of attention as interesting tools for ample biomedical applications especially bio-imaging due to their brightness and photo-stability. Numerous AIEgens have been developed for lighting up the sub-cellular organelles to understand their forms and functions in healthy as well as diseased states like cancer. However, there is a serious absence of easily synthesizable, biocompatible small molecules for illuminating mitochondria (powerhouses) inside cells. To address this, in this report we describe an easy and short synthesis of novel biocompatible hydrazide-hydrazone based small molecules with remarkable aggregation-induced emission (AIE) property. These small molecule AIEgens showed hitherto unobserved AIE property due to dual intra-molecular H-bonding confirmed by theoretical calculation, pH and temperature dependent fluorescence and X-ray crystallography studies. Confocal microscopy showed that these AIEgens were internalized into the HeLa cervical cancer cells without showing any cytotoxicity. One of the AIEgens was tagged with triphenylphosphine (TPP) moiety which successfully localized into mitochondria of HeLa cells selectively compared to L929 non-cancerous fibroblast cells. These unique hydrazide-hydrazone based biocompatible AIEgens can serve as powerful tools to illuminate multiple sub-cellular organelles to elucidate their forms and functions in cancer cells for nextgeneration biomedical applications.by Sohan Patil, Shalini Pandey, Amit Singh, Mithun Radhakrishna, Sudipta Bas

Consequences of μ-τ reflection symmetry for 3+1 neutrino mixing

We investigate the consequences of ??? reflection symmetry in presence of a light sterile neutrino for the 3+1 neutrino mixing scheme. We discuss the implications of total ??? reflection symmetry as well partial ??? reflection symmetry. For the total ??? reflection symmetry we find values of ?23 and ? remains confined near ?/4 and �?/2 respectively. The current allowed region for ?23 and ? in case of inverted hierarchy lies outside the area preferred by the total ??? reflection symmetry. However, interesting predictions on the neutrino mixing angles and Dirac CP violating phases are obtained considering partial ??? reflection symmetry. We obtain predictive correlations between the neutrino mixing angle ?23 and Dirac CP phase ? and study the testability of these correlations at the future long baseline experiment DUNE. We find that while the imposition of ??? reflection symmetry in the first column admit both normal and inverted neutrino mass hierarchy, demanding ??? reflection symmetry for the second column excludes the inverted hierarchy. Interestingly, the sterile mixing angle ?34 gets tightly constrained considering the ??? reflection symmetry in the fourth column. We also study consequences of ??? reflection symmetry for the Majorana phases and neutrinoless double beta decay.by KaustavChakraborty, Srubabati Goswami and Biswajit Karmaka