Alphitobius diaperinus larvae (lesser mealworm) as human food – An approval of the European Commission – A critical review

Due to the increasing threat of climate change and the need for sustainable food sources, human consumption of edible insects or entomophagy has gained considerable attention globally. The larvae of Alphitobius diaperinus Panzer (Coleoptera: Tenebrionidae), also known as the lesser mealworm, have been identified as a promising candidate for mass-rearing as a food source based the on evaluation on several aspects such as the production process, the microbiological and chemical composition, and the potential allergenicity to humans. As a consequence, the European Commission has recently approved the utilization of lesser mealworms as human foods. Lesser mealworms are considered a good source of protein, with a protein content ranging from 50-65% of their dry weight and containing various essential amino acids. Lesser mealworms are also rich in other essential nutrients such as iron, calcium, and vitamins B12 and B6. Furthermore, the hydrolysates of lesser mealworms are known to contain antioxidants, suggesting the therapeutic properties of the insects. To enable and ensure a continuous supply of lesser mealworms, various rearing procedures of the insects and information on optimal environmental rearing conditions have been reported. However, like other edible insects, lesser mealworms are still not commonly consumed in Western countries because of various consumer- and product-related factors. Ultimately, the European Commission’s approval of lesser mealworms as a novel food is a key milestone in the development of the insect food industry. Embracing the consumption of edible insects can help address the challenges of feeding a growing population, mitigate the environmental impact of food production, and promote a more sustainable and resilient food system for the future

Preclinical Development of a Novel Epitope-based DNA Vaccine Candidate against SARS-CoV-2 and Evaluation of Immunogenicity in BALB/c Mice

The protective efficacies of current licensed vaccines against COVID-19 have significantly reduced as a result of SARS-CoV-2 variants of concern (VOCs) which carried multiple mutations in the Spike (S) protein. Considering that these vaccines were developed based on the S protein of the original SARS-CoV-2 Wuhan strain, we designed a recombinant plasmid DNA vaccine based on highly conserved and immunogenic B and T cell epitopes against SARS-CoV-2 Wuhan strain and the Omicron VOC. Literature mining and bioinformatics were used to identify 6 immunogenic peptides from conserved regions of the SARS-CoV-2 S and membrane (M) proteins. Nucleotide sequences encoding these peptides representing highly conserved B and T cell epitopes were cloned into a pVAX1 vector to form the pVAX1/S2-6EHGFP recombinant DNA plasmid vaccine. The DNA vaccine was intranasally or intramuscularly administered to BALB/c mice and evaluations of humoral and cellular immune responses were performed. The intramuscular administration of pVAX1/S2-6EHGFP was associated with a significantly higher percentage of CD8+ T cells expressing IFN-γ when compared with the empty vector and PBS controls. Intramuscular or intranasal administrations of pVAX1/S2-6EHGFP resulted in robust IgG antibody responses. Sera from mice intramuscularly immunized with pVAX1/S2-6EHGFP were found to elicit neutralizing antibodies capable of SARS-CoV-2 Omicron variant with the ACE2 cell surface receptor. This study demonstrated that the DNA vaccine construct encoding highly conserved immunogenic B and T cell epitopes was capable of eliciting potent humoral and cellular immune responses in mice

Breaking the stigma against male nurses

Nurses serve as primary-care practitioners, assuming responsibility for treatment, safety, and recovery of patients. For ages, the nursing profession has been traditionally associated with women. Early accounts of nurses exclusively mention women, even though men and women both assisted in patient care back then

Sustainable degradation of synthetic plastics: A solution to rising environmental concerns

Plastics have a significant role in various sectors of the global economy since they are widely utilized in agriculture, architecture, and construction, as well as health and consumer goods. They play a crucial role in several industries as they are utilized in the production of diverse things such as defense materials, sanitary wares, tiles, plastic bottles, artificial leather, and various other household goods. Plastics are utilized in the packaging of food items, medications, detergents, and cosmetics. The overconsumption of plastics presents a significant peril to both the ecosystem and human existence on Earth. The accumulation of plastics on land and in the sea has sparked interest in finding ways to breakdown these polymers. It is necessary to employ suitable biodegradable techniques to decrease the accumulation of plastics in the environment. To address the environmental issues related to plastics, it is crucial to have a comprehensive understanding of the interaction between microorganisms and polymers. A wide range of creatures, particularly microbes, have developed techniques to survive and break down plastics. This review specifically examines the categorization of plastics based on their thermal and biodegradable properties, as well as the many types of degradation and biodegradation. It also discusses the various types of degradable plastics, the characterization of biodegradation, and the factors that influence the process of biodegradation. The plastic breakdown and bioremediation capabilities of these microbes make them ideal for green chemistry applications aimed at removing hazardous polymers from the ecosystem

Why doctors should empower parents, not dismiss symptoms of developmental delay

IN A majority of children’s developmental delay cases, parents often consult professionals about their concerns, or for a diagnosis to better explain and understand their child’s unusual behaviour or delayed development. They hope to gain more insight into what is going on and what they can expect in the future. But as parents, have you had your healthcare professional deny, dismiss, downplay or discredit concerns about your child’s development

Problematic gaming in Malaysian University students: translation and psychometric evaluation of the Malay Language Versions of Gaming Disorder Test and Gaming Disorder Scale for Young Adults

As research on gaming disorder (GD) is growing globally, the need for a valid and reliable instrument to assess GD has become crucial. Therefore, the present cross-sectional study translated and evaluated the psychometric properties of Gaming Disorder Test (GDT) and Gaming Disorder Scale for Young Adults (GADIS-YA) into Malay language versions. The sample comprised 624 university students (females = 75.6%; mean age = 22.27 years) recruited via an online survey from May to August 2022, using a convenience sampling method. Participants completed both GDT and GADIS-YA scales and other relevant measures including Bergen Social Media Addiction Scale (BSMAS), Internet Gaming Disorder Scale-Short Form (IGDS9-SF), and time spent on social media and gaming. Results showed that both instruments reported satisfactory internal consistency, and confirmatory factor analysis supported the one-factor structure for GDT and two-factor structure for GADIS-YA. Both scales were strongly correlated with each other and with the IGDS9-SF, BSMAS, and time spent on social media and gaming, supporting concurrent validity. Measurement invariance of both scales was confirmed across gender and gaming time. These findings suggest that the Malay versions of GDT and GADIS-YA are reliable and valid measures of problematic gaming among Malaysian university students

NOMA-based retrodirective frequency diverse array for multi-user communication

Frequency Diverse Array (FDA) and retrodirective array have found applications in wireless communication networks, offering cost-effective and efficient beamforming capabilities. In this paper, a novel concept of the retrodirective frequency diverse array (RFDA) is introduced, which empowers each array element to handle multiple communication channels, thereby enabling support for multiple users. This is made possible by utilizing the non-orthogonal multiple access (NOMA) scheme. The antenna elements are organized in a uniform circular array configuration. The system supports the multitude of users by assigning them into distinct clusters based on the serving antenna and then allocating transmit power to each user based on their respective channel conditions and distances from the base station. Consequently, efficient schemes for user clustering and power allocation tailored to the NOMA-RFDA system are developed. As a result, multi-user connectivity is achieved while maintaining low design costs. The simulation outcomes affirm that the proposed system attains superior performance in terms of both data rate and energy efficiency when compared to similar reference schemes

Driving home the message about salt

According to the World Health Organisation (WHO), non-communicable diseases (NCDs) are the main cause of mortality and disability in Malaysia. Known as "silent killers", NCDs continue to claim lives despite being largely preventable

Changes in social norms during the early stages of the COVID-19 pandemic across 43 countries

The emergence of COVID-19 dramatically changed social behavior across societies and contexts. Here we study whether social norms also changed. Specifically, we study this question for cultural tightness (the degree to which societies generally have strong norms), specific social norms (e.g. stealing, hand washing), and norms about enforcement, using survey data from 30,431 respondents in 43 countries recorded before and in the early stages following the emergence of COVID-19. Using variation in disease intensity, we shed light on the mechanisms predicting changes in social norm measures. We find evidence that, after the emergence of the COVID-19 pandemic, hand washing norms increased while tightness and punishing frequency slightly decreased but observe no evidence for a robust change in most other norms. Thus, at least in the short term, our findings suggest that cultures are largely stable to pandemic threats except in those norms, hand washing in this case, that are perceived to be directly relevant to dealing with the collective threat

Factors Influencing Students’ Cheating Behaviours: an Empirical Evidence from China.

There is an ample evidence to show how students’ cheating behaviours formed in Western countries, comparatively, few studies focused on Chinese students. The purpose of this study is to measure the influence of attitude, subjective norm (SN), perceived behavioural control (PBC), and additional variable which is moral obligation on intention among Chinese students who were studying in China and the U.K. A total of 540 useable questionnaires were collected based on web-based method for further hypotheses testing. The results show that attitude, SN, PBC and moral obligation positively influence intention to cheat respectively. The SN displays significant positive influence on attitude and moral obligation. In addition, statistically significant differences in SN, PBC and intention were obtained between gender, majors and educational level and studying places which show that males had more intention than females on cheating. Major of management students had more PBC than engineering and economics students, fresh and sophomore had more PBC than junior students, and students who were studying in U.K are more influenced by SN compared to who were studying in China. This study enriches the existing knowledge on how Chinese students’ attitude, SN, PBC and moral obligation on cheating intention based on divergent demographic characteristics