Bewegung und Bewegungsförderung von Mädchen beim Schulübergang. Quantitative Daten zur körperlich-sportlichen Aktivität von Mädchen im Übergang von der Kita in die 1. Klasse

Der Beitrag stellt zentrale Befunde zur Veränderung der körperlich-sportlichen Aktivität von Mädchen, welche sich im Übergang vom Kindergarten in die 1. Klasse befinden, vor

Effects of Bi and Sb ion incorporation on the optoelectronic properties of mixed lead–tin perovskites

Doping with small densities of foreign ions is an essential strategy for tuning the optoelectronic properties of semiconductors, but the effects of doping are not well-understood in halide perovskites. We investigate the effect of Bi3+ and Sb3+ doping in lead–tin perovskites. Films doped with small amounts of BiI3 and SbI3 show greatly increased non-radiative recombination at precursor doping concentrations as low as 1 ppm for Bi3+ and 1000 ppm for Sb3+. We rationalize such behaviour by density functional theory (DFT) simulations, showing that these metal ions can be incorporated in the perovskite crystal by introducing deep trap levels in the band gap. Having found that very small amounts of Bi3+ greatly reduce the optoelectronic quality of lead–tin perovskite films, we investigate the presence of Bi impurities in perovskite precursor chemicals and find quantities approaching 1 ppm in some. In response, we introduce a facile method for removing Bi3+ impurities and demonstrate removal of 100 ppm Bi from a perovskite ink. This work demonstrates how the incorporation of small concentrations of foreign metal ions can severely affect film quality, raising the importance of precursor chemical purity

Discovery of cilnidipine cocrystals with enhanced dissolution by the use of computational tools and semiautomatic high-throughput screening

Cocrystals are an attractive option for overcoming drug limitations, such as a low dissolution rate and absorption of poorly water-soluble compounds. Nevertheless, the discovery of new cocrystals remains a trial-and-error approach in which hundreds of coformers and several experimental methods are often tested. To streamline the cocrystal screening, computational methods can be used to select the coformers most likely to form a cocrystal, while high-throughput screening (HTS) approaches can rapidly screen them experimentally. In this manuscript, a new cocrystal of the extremely poorly soluble drug cilnidipine (solubility ≈30 ng/mL, 0.06 μM) was successfully discovered by applying HTS approaches. Only one cocrystal resulted from the screening with a total of 52 coformers, whereby the computational approach molecular complementarity successfully ranked this coformer (p-toluenesulfonamide) at the third position of the screening list. Dissolution studies conducted on the cocrystal in blank FaSSIF (fasted-state simulated intestinal fluid) and FaSSIF pH 6.5 revealed enhanced drug dissolution with a maximum achieved supersaturation equal to seven times the solubility of the crystalline drug. Dissolution rates of drug and coformer were compared for better mechanistic understanding of the cocrystal dissolution–supersaturation–precipitation behavior. The case of cilnidipine with a rare occurrence of cocrystals emphasized the importance of using joint computational and HTS approaches to enable successful cocrystal identification for pharmaceutical development

Future Health: Die Gesundheitsförderung von morgen in Schweizer Betrieben

Der BGM-Monitor 2024 zeigt auf, wo Schweizer Betriebe die grössten Herausforderungen sehen und in welche Bereiche sie zukünftig investieren wollen, um die Gesundheit ihrer Mitarbeitenden zu fördern. Dieser Vortrag liefert inspirierende Einblicke und konkrete Strategien, wie Betriebe ihre Gesundheitsförderung systematisch weiterentwickeln und den Anforderungen der Zukunft aktiv begegnen können.https://www.praxisevent-psychologie.c

Machine Learning for Supporting the Processing of Post-Trading Fees

This research explores the potential of machine learning to address these challenges by automating the categorisation and processing of these fees, with the aim of reducing manual input, minimising errors and improving overall efficiency

Die Rolle der ärztlichen Führungskraft

https://www.vlss.ch/fileadmin/user_upload_verein/5-Publikationen/VLSS-Info/2025/VLSS_Info_1_2025_DE.pd